| 2021-08-14 15:00:20Sat 14 Aug 2021 | Clitheroe vs 1874 Northwich | 2 - 2 | Shawbridge |
| 2021-08-17 19:45:09Tue 17 Aug 2021 | 1874 Northwich vs Kidsgrove Athletic | 0 - 3 | Townfield Lane |
| 2021-08-23 19:45:49Mon 23 Aug 2021 | Market Drayton Town vs 1874 Northwich | 0 - 1 | |
| 2021-08-28 15:00:47Sat 28 Aug 2021 | 1874 Northwich vs Kendal Town | 4 - 1 | Townfield Lane |
| 2021-08-30 15:00:35Mon 30 Aug 2021 | Runcorn Linnets vs 1874 Northwich | 1 - 0 | Millbank Linnets Stadium |
| 2021-09-07 19:45:21Tue 7 Sep 2021 | 1874 Northwich vs Leek Town | 0 - 3 | Townfield Lane |
| 2021-09-11 15:00:09Sat 11 Sep 2021 | 1874 Northwich vs Marine | 0 - 2 | Townfield Lane |
| 2021-09-14 19:45:53Tue 14 Sep 2021 | 1874 Northwich vs Newcastle Town | 1 - 1 | Townfield Lane |
| 2021-09-25 15:00:43Sat 25 Sep 2021 | Workington vs 1874 Northwich | 2 - 2 | Borough Park |
| 2021-10-02 15:00:33Sat 2 Oct 2021 | 1874 Northwich vs Bootle | 0 - 5 | Townfield Lane |
| 2021-10-12 19:45:37Tue 12 Oct 2021 | City of Liverpool vs 1874 Northwich | 0 - 1 | Rivacre Park |
| 2021-10-16 15:00:31Sat 16 Oct 2021 | 1874 Northwich vs Colne | 1 - 2 | Townfield Lane |
| 2021-10-23 15:00:25Sat 23 Oct 2021 | Prescot Cables vs 1874 Northwich | 1 - 2 | Volair Park |
| 2021-11-06 15:00:43Sat 6 Nov 2021 | 1874 Northwich vs Ramsbottom United | 1 - 0 | Townfield Lane |
| 2021-11-13 15:00:48Sat 13 Nov 2021 | Glossop North End vs 1874 Northwich | 1 - 1 | The Arthur Goldthorpe Stadium |
| 2021-11-20 15:00:42Sat 20 Nov 2021 | Trafford vs 1874 Northwich | 2 - 5 | Home Estates Shawe View |
| 2021-11-27 15:00:43Sat 27 Nov 2021 | 1874 Northwich vs Widnes | 0 - 3 | Townfield Lane |
| 2021-12-04 15:00:59Sat 4 Dec 2021 | 1874 Northwich vs Mossley | 7 - 3 | Townfield Lane |
| 2021-12-11 14:00:29Sat 11 Dec 2021 | Kidsgrove Athletic vs 1874 Northwich | 1 - 3 | Novus Stadium |
| 2021-12-18 15:00:19Sat 18 Dec 2021 | 1874 Northwich vs Clitheroe | 2 - 2 | Townfield Lane |
| 2022-01-01 15:00:16Sat 1 Jan 2022 | 1874 Northwich vs Runcorn Linnets | 1 - 2 | Townfield Lane |
| 2022-01-15 15:00:36Sat 15 Jan 2022 | 1874 Northwich vs Workington | 2 - 4 | Townfield Lane |
| 2022-01-22 15:00:04Sat 22 Jan 2022 | Colne vs 1874 Northwich | 0 - 4 | The XLCR Stadium |
| 2022-01-29 15:00:00Sat 29 Jan 2022 | 1874 Northwich vs Prescot Cables | 0 - 1 | Townfield Lane |
| 2022-02-08 19:45:57Tue 8 Feb 2022 | 1874 Northwich vs Glossop North End | 0 - 1 | Townfield Lane |
| 2022-02-12 15:00:04Sat 12 Feb 2022 | Warrington Rylands vs 1874 Northwich | 3 - 1 | Rylands Recreation Club |
| 2022-02-26 15:00:27Sat 26 Feb 2022 | 1874 Northwich vs City of Liverpool | 2 - 2 | Townfield Lane |
| 2022-03-01 19:45:01Tue 1 Mar 2022 | Ramsbottom United vs 1874 Northwich | 2 - 0 | The Harry Williams Stadium |
| 2022-03-05 15:00:28Sat 5 Mar 2022 | Bootle vs 1874 Northwich | 3 - 2 | Berry Street Garage Stadium |
| 2022-03-12 15:00:43Sat 12 Mar 2022 | Marine vs 1874 Northwich | 1 - 0 | The Marine Travel Arena |
| 2022-03-19 15:00:44Sat 19 Mar 2022 | Leek Town vs 1874 Northwich | 1 - 2 | Harrison Park |
| 2022-03-26 15:00:03Sat 26 Mar 2022 | Widnes vs 1874 Northwich | 1 - 1 | Select Security Stadium |
| 2022-03-29 19:45:34Tue 29 Mar 2022 | Newcastle Town vs 1874 Northwich | 0 - 1 | Red Industries Stadium |
| 2022-04-02 15:00:28Sat 2 Apr 2022 | 1874 Northwich vs Trafford | 3 - 0 | Townfield Lane |
| 2022-04-09 15:00:26Sat 9 Apr 2022 | 1874 Northwich vs Market Drayton Town | 7 - 0 | Townfield Lane |
| 2022-04-16 15:00:21Sat 16 Apr 2022 | Kendal Town vs 1874 Northwich | 0 - 0 | ST&B Accountants Stadium |
| 2022-04-18 15:00:44Mon 18 Apr 2022 | 1874 Northwich vs Warrington Rylands | 0 - 1 | Townfield Lane |
| 2022-04-23 15:00:31Sat 23 Apr 2022 | Mossley vs 1874 Northwich | 1 - 0 | Seel Park |
